Gene Expression in Liver

20,000 protein-coding genes are expressed in human cells, with 60 percent of these genes expressed in a typical adult liver. In the liver, about 400 genes are expressed more specifically, with 150 of them being highly specific to liver tissue. Hepatocytes express the majority of the associated liver-specific proteins, which are then released into the bloodstream to create plasma proteins. Other liver-specific proteins include liver enzymes such as HAO1 and RDH16, bile-producing proteins such as BAAT and SLC27A5, and drug transporter proteins such as ABCB11 and SLC2A2. The fibrinogen beta chain proteins, apolipoprotein A II, coagulation factors F2 and F9, complement factor related proteins, and apolipoprotein A II are all liver-specific proteins.

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