Gene Expression in Liver
Hepatocytes express the majority of the linked liver-specific proteins, which are then unconfined into the bloodstream to create plasma proteins. Other liver-specific proteins have liver enzymes such as HAO1 and RDH16, bile-producing proteins such as BAAT and SLC27A5, and drug carrier proteins such as ABCB11 and SLC2A2. The fibrinogen beta chain proteins, apolipoprotein A II, coagulation factors F2 and F9, complement factor linked proteins, and apolipoprotein A II are all liver-specific proteins. 20,000 protein-coding genes are expressed in human cells, with 60 percentage of these genes expressed in a typical adult liver. In the liver, about 400 genes are expressed further in detail, with 150 of them being exceedingly specific to liver tissue.
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