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World Congress on Pancreatic Cancer and Liver Diseases, will be organized around the theme “Daring Innovations in Enriching the HEALTH against Pancreatic and Liver disorders”

Pancreas 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pancreas 2019

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Pancreas is one of the principal chemists of the body that produce hormones exocrine and endocrine to aid in the digestion of food. It comprises distinctive types of pancreatic cells. The exocrine cells consist of acinar cells and the endocrine cells are present in clusters of cells called the islets of Langerhans. The Islets of Langerhans function with the help of pancreatic alpha, beta, delta and gamma cells. The gallbladder is a small sac-shaped organ below the liver, wherein the bile secreted by the liver is stored, before releasing into the intestine. Genetic screening studies have facilitated identify gene mutations that lead to pancreatic diseases and in identifying the changes in the pancreatic cells affected by diseases.

  • Track 1-1Exocrine pancreas
  • Track 1-2 Pancreatic and periampullary carcinoma
  • Track 1-3Adenocarcinoma of pancreas
  • Track 1-4Pancreas histology
  • Track 1-5Pancreas atrophy
  • Track 1-6Pancreas function
  • Track 1-7Retroperitonial pancreas
  • Track 1-8Overactive pancreas
  • Track 1-9Enlarged pancreas
  • Track 1-10Endocrine pancreas
  • Track 1-11 Innovation in Pancreatic Cancer Treatment

Pancreatic diseases comprise acute and chronic pancreatitis characterized by severe inflammation of the pancreas. Pancreatitis may also be categorized as hereditary pancreatitis and necrotizing pancreatitis. Other disorders of the pancreas consist of endocrine and exocrine syndromes, Zollinger-Ellison syndrome. Pancreatic divisum is a congenital disorder in which the pancreas is not combined but it will present as two to three different parts.

  • Track 2-1Acute pancreatitis
  • Track 2-2Chronic pancreatitis
  • Track 2-3Pancreatic Necrosis
  • Track 2-4 Pancreatic ducts
  • Track 2-5Acute pancreatitis pathophysiology
  • Track 2-6 Alcoholic pancreatitis
  • Track 2-7 Symptoms of pancreatitis

Cystic Fibrosis of the pancreas is a disorder that progresses due to inadequate development of sodium bicarbonate in the body. This leads to thickening of pancreatic enzymes due to dehydration. This may obstruct the pancreatic ducts from allowing the production of pancreatic enzymes passage into the small intestine. Ultimately this condition will lead to fibrosis of the pancreas.

  • Track 3-1Advanced treatment for IPMN pancreas
  • Track 3-2Pseudocyst of pancreas
  • Track 3-3Advanced diagnosis for IPMN pancreas

The exocrine cells comprise acinar cells and the endocrine cells are present in clusters of cells called the islets of Langerhans. The Islets of Langerhans function in the production of hormones insulin and glucagon, somatostatin and pancreatic enzymes with the support of pancreatic alpha, beta, delta and gamma cells.  Pancreatic insufficiency is the incompetence to properly digest food due to a deficiency of digestive enzymes produced by the pancreas. Diabetes leads to many alterations in the glucose metabolism rates between those afflicted by the disease and those not. The other pancreatic enzymes trypsin, amylase and pancreatic lipase also result in the proper absorption and digestion of nutrients by the small intestine.

  • Track 4-1Elevated pancreatic enzymes
  • Track 4-2Pancreatic pseudocyst
  • Track 4-3Pancreatic enzymes replacements
  • Track 4-4Pancreatic enzymes supplements

Pancreas  is an organ, which plays a major role in digestion and hormone production. Disorders of pancreas include acute pancreatitis, pancreatic cancer and hereditary pancreatitis. The journal stocks up information about pancreatic disorders, methods of detection, different therapies and advanced treatments to overcome pancreatic disorders.

  • Track 5-1Pancreatic Cancer
  • Track 5-2Cystic fibrosis
  • Track 5-3 Diabetes Mellitus
  • Track 5-4Immunotherapeutic Approaches in Pancreatic Cancer

Surgery is often part of the treatment for pancreatic cancer if it can be done. Depending on the type and stage of your cancer, surgery might be used to remove the cancer and part or your entire pancreas. Ablation or embolization is another way of destroying the tumors without surgery. Anti-cancer drugs are either introduced by injecting into the veins or by oral administration. Chemotherapy and Radiation therapy are sometimes used simultaneously. Whipple procedures are surgical removal of cancerous pancreatic parts. This also includes pancreaticoduodenectomy and pylorous preserving whipple.

  • Track 6-1Pancreatic tumors
  • Track 6-2Benign pancreatic tumors
  • Track 6-3Pancreatic neuroendocrine tumors
  • Track 6-4Pancreatic Oncology
  • Track 6-5Pancreatic ductal adenocarcinoma (PDAC)
  • Track 6-6Vaccine in Pancreatic Cancer
  • Track 6-7Advances in pancreatic cyst surgery

Pancreatic Cancer and the numerous diseases associated with this organ have been in the top priority of most researchers in the field of research. In the past, the number of people dying of pancreatic cancer and its various diseases had increased to an extent that currently, it has become the fourth most common cause of Cancer Death in the United States. Researchers have been focused on finding advanced treatment techniques for this cancer type. Including high alcoholism, there are number of causes that lead to malfunction or disrupt the normal metabolism of this organ.

  • Track 7-1Acute pancreatitis prognosis
  • Track 7-2Chronic pancreatitis prognosis
  • Track 7-3Pancreatic cancer prognosis

Imaging tests used to diagnose pancreatic cancer include ultrasound, computerized tomography (CT) scan and Magnetic Resonance Imaging (MRI). The CT scan uses x-rays to produce detailed cross-sectional images of your body. CT scans are often used to diagnose pancreatic cancer because they can show the pancreas clearly. MRI scans use radio waves and strong magnets instead of x-rays. The energy from the radio waves is absorbed by the body and then released in a pattern formed by the type of body tissue and by certain diseases.

  • Track 8-1Pancreatic cysts
  • Track 8-2Pancreatic cancer diagnosis
  • Track 8-3Advanced pancreatitis diagnosis
  • Track 8-4Molecular Diagnostics to Pancreatic Cancer
  • Track 8-5Biomarkers in pancreatic cancer
  • Track 8-6RTPCR
  • Track 8-7Western Blot Analysis and Albumin ELISA
  • Track 8-8Immunofluorescence and Immunohistochemistry

Replacing of diseased pancreas with a healthy pancreas is pancreatic transplantation. Different transplant methods include Pancreas Alone Transplant, Liver-Pancreas Transplant, Pancreas after Kidney Transplant and Simultaneous Kidney Pancreas Transplant. Islet Cell Transplantation involves only the transplantation of Islet cells. Care is taken that the grafts are accepted with the help of immunosuppressant and new anesthesia techniques.

  • Track 9-1Pancreatectomy
  • Track 9-2Hepato-Biliary-Pancreatic Surgery
  • Track 9-3Pancreas transplantation
  • Track 9-4Islet Autotransplantation
  • Track 9-5Artificial Pancreas
  • Track 9-6Pancreas transplant success rate

Positron emission tomography (PET) Scan is done to image the area of cancer by injecting radioactive sugars. Magnetic Resonance Cholangiopancreatography (MRCP) is used to look at the pancreas. This test is not used for biopsies. Endoscopic Retrograde Cholangiopancreatography (ERCP) is used to check for pancreatic cancer and any blocks by injecting a dye through endoscopy. This test can also be used for biopsies. Endoscopic ultrasound is done with a small ultrasound probe attached to endoscope. Biopsy is most commonly done by laparoscopy. Trans abdominal ultrasound examination is used to detect cancers and stones in the gall bladder. Case reports of such diagnosis and clinical trials will be discussed in this session.

  • Track 10-1Early Detection of Sporadic Pancreatic Cancer
  • Track 10-2Acute pancreatitis treatment
  • Track 10-3Chronic pancreatitis treatment
  • Track 10-4Pancreaticobiliary Endoscopy
  • Track 10-5Feline pancreatitis treatment
  • Track 10-6Pancreatic pseudocyst treatment
  • Track 10-7Natural treatment for pancreatitis
  • Track 10-8Medical breakthroughs in prevention, diagnosis and treatment

The liver is the body’s largest internal organ that sits on the right hand side of the belly. It is an essential organ that has many functions in the body, including making proteins and blood clotting factors, manufacturing triglycerides and  cholesterol, glycogen synthesis and bile production. The liver filters the blood coming from the digestive tract and detoxifies the chemicals and metabolizes the vitamins, proteins, fats, carbohydrates and drugs. The liver secrets the bile that ends up back in the intestine.

  • Track 11-1Bile Production and Excretion
  • Track 11-2Blood Detoxification and Purification
  • Track 11-3Synthesis of Plasma Proteins
  • Track 11-4Metabolism of Fats, Proteins and Carbohydrates

The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. The healthy liver is also a site of complex immunological activity mediated by a diverse immune cell repertoire as well as non-hematopoietic cell populations. In the non-diseased liver, metabolic and tissue remodeling functions require elements of inflammation. In this complex microenvironment, the hepatic immune system tolerates harmless molecules while at the same time remaining alert to possible infectious agents, malignant cells or tissue damage.

In the healthy liver, constantly changing metabolic and tissue remodeling activity, combined with regular exposure to microbial products, results in persistent, regulated inflammation. These inflammatory processes act in a tightly controlled fashion and are stimulated to additional activity only when the liver is required to rid itself of hepatotropic pathogens, malignant cells or toxic products of metabolic activity. Failure to clear such dangerous stimuli and resolve inflammation, leads to chronic infection, autoimmunity or tumor growth. This is inevitably associated with chronic pathological inflammation and disrupted tissue homeostasis, which can progress to fibrosis, cirrhosis and liver failure.

  • Track 12-1Liver Immune Tolerance
  • Track 12-2Hepatic Innate Immunity
  • Track 12-3Liver Sinusoidal Endothelial Cells
  • Track 12-4Liver as an Immunological Organ

Histological examinations of liver biopsy before treatment showed accumulation of fat within the hepatocytes, bile duct endothelium and epithelium and kupffer cells which contain the portal macrophages. The liver serves as the filtration ground of absorbed intestinal luminal contents which are particularly susceptible to microbial antigens.

  • Track 13-1Cholestasis
  • Track 13-2Peliosis hepatis
  • Track 13-3Transudative Ascites
  • Track 13-4Centrilobular Necrosis

Hepatobiliary diseases are diseases that affect the biliary tract or the liver. Cholangiocarcinoma is usually a bile duct that presents a malignant tumor. Treating the disease requires removal and/or resection. Biliary structures (both malignant and benign) – occur when the bile ducts become inflamed or injured. The ducts narrow and form a stricture. They are often caused by injury or cancer. Bile duct stones – are stones that occur within the bile duct, similar to a gallstone. They often start developing in the gallbladder and make their way into the bile duct. The hepatobiliary system is made up of the liver, gall bladder and bile ducts. Conditions or diseases that cause harm to these areas, which can be life threatening, are referred to as hepatobiliary diseases.

Caroli disease and Caroli syndrome are rare congenital disorders of the intrahepatic bile ducts. They are both characterized by dilatation of the intrahepatic biliary tree. The term Caroli disease is applied if the disease is limited to ectasia or segmental dilatation of the larger intrahepatic ducts. Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Neonatal hemochromatosis is a syndrome in which severe liver disease of fetal or perinatal onset is associated with deposition of stainable iron in extrahepatic sites. Survival rates in babies who undergo liver transplantation are reportedly 50%.

  • Track 14-1Acute liver failure
  • Track 14-2Biliary atresia
  • Track 14-3Pediatric Caroli disease
  • Track 14-4Cholangiocarcinoma (biliary tree cancer)
  • Track 14-5Primary Neonatal Hemochromatosis

A liver metastasis is a cancerous tumor that has spread to the liver from cancer that started in another place in the body. It’s also called secondary liver cancer. Primary liver cancer originates in the liver and most commonly affects individuals who have risk factors such as hepatitis or cirrhosis. Cancer in the liver is secondary, or metastatic. There may be no symptoms in the early stages of liver metastasis. In later stages, cancer can cause the liver to swell or obstruct the normal flow of blood and bile. When this happens, loss of appetite, weight loss, dark-colored urine, abdominal swelling or bloating, jaundice, a yellowing of the skin or the whites of the eyes, pain in the right shoulder, pain in the upper right abdomen, nausea, vomiting, confusion, sweats, and fever, enlarged liver.

  • Track 15-1Symptoms of Liver Metastasis
  • Track 15-2Liver Metastasis-Diagnosis
  • Track 15-3Supportive Therapies
  • Track 15-4Treatments

Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. Cirrhosis occurs in response to damage to your liver. Each time your liver is injured, it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function. Cirrhosis occurs in response to damage to your liver. Each time your liver is injured, it tries to repair itself. In the process, scar tissue forms. As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function which include Fluid accumulation in your abdomen (ascites), Confusion, drowsiness and slurred speech (hepatic encephalopathy), Testicular atrophy in men, Breast enlargement in men. Cirrhosis can also cause portal hypertension, Enlargement of the spleen (splenomegaly).

  • Track 16-1Causes of Liver Cirrhosis
  • Track 16-2Prevention of Liver Cirrhosis
  • Track 16-3Liver Cirrhosis- Symptoms
  • Track 16-4Treatments 

Hepatitis refers to an inflammatory condition of the liver. It’s commonly caused by a viral infection, but there are other possible causes of hepatitis. These include autoimmune hepatitis and hepatitis that occurs as a secondary result of medications, drugs, toxins, and alcohol. Autoimmune hepatitis is a disease that occurs when your body makes antibodies against your liver tissue. Viral infections of the liver that are classified as hepatitis include hepatitis A, B, C, D, and E. A liver biopsy is an invasive procedure that involves your doctor taking a sample of tissue from your liver. This test allows your doctor to determine how infection or inflammation has affected your liver. Corticosteroids, like prednisone or budesonide, are extremely important in the early treatment of autoimmune hepatitis.

  • Track 17-1Viral Hepatitis
  • Track 17-2Auto-immune Hepatitis
  • Track 17-3 Alcoholic hepatitis

Hepatitis is an inflammation of the liver characterized by diffuse or patchy necrosis. Autoimmune hepatitis (AIH) is one exception. This type of liver disease occurs when your immune system attacks your liver cells. AIH is a chronic condition that can result in cirrhosis (scarring) of the liver. certain risk factors have been identified, including mainly a family history of AIH. Autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. It occurs more frequently in females. Treatment typically includes corticosteroids and medications that suppress the immune system. In severe cases, a liver transplant may be needed. Ischemic hepatitis differs from other types of hepatitis. Which can have many causes, most commonly a virus (as in hepatitis A or B). However, in ischemic hepatitis, the liver is not inflamed. Rather, liver cell death(necrosis) occurs. The term hepatitis is used because technically, it refers to any disorder in which enzymes called aminotransferases leak from damaged liver cells into the blood.

  • Track 18-1Genetic disorders leading to Hepatitis
  • Track 18-2Ischemic Hepatitis
  • Track 18-3Autoimmune Hepatitis
  • Track 18-4Infectious Hepatitis

To diagnose hepatitis, first your doctor will take your history to determine any risk factors you may have for infectious or noninfectious hepatitis. Liver function tests use blood samples to determine how efficiently your liver works.

High liver enzyme levels may indicate that your liver is stressed, damaged, or not functioning properly. An abdominal ultrasound uses ultrasound waves to create an image of the organs within your abdomen. It can reveal Liver tumors, Liver failure, Abnormalities of gall bladder. Treatment options are determined by which type of hepatitis you have and whether the infection is acute or chronic.

  • Track 19-1Vaccination
  • Track 19-2Immunization
  • Track 19-3 Liver Transplant
  • Track 19-4 Anti-viral Drug Therapies

Viruses are the intracellular parasites that depend on synthetic processes of host cells. They cannot be grown on ordinary medium. Special microscopes are needed to visualize their structure, which consists of Genome (genetic material consisting of DNA or RNA component but never both), Surrounding capsid –proteinaceous in structure, Envelope –protein bilayer. Hepatitis B virus (HBV) is an important cause of end-stage liver disease and hepatocellular carcinoma (HCC). The decision to treat is based on the activity of liver disease and HBV replication status, and the likelihood of a long-term benefit. Approved therapies include standard and pegylated interferon-alfa and nucleoside analogues: lamivudine, adefovir and entecavir. Even with successful therapy, patients remain at risk for reactivation of viral replication and require lifelong monitoring.

HBV in HBsAg-positive patients treated with allogeneic hematopoietic cell transplantation. Highly active antiretroviral therapy is initiated for decreasing mortality relating to HIV. Influenza can be type A, B or C depending upon type. Influenza A and B are more common.

  • Track 20-1Anti-retroviral agents
  • Track 20-2 Antiviral Regimens
  • Track 20-3 Anti-herpes virus agents
  • Track 20-4 Anti influenza agents

It's not something you probably think much about, but your liver is a key player in your body's digestive system. Everything you eat or drink, including medicine, passes through it. You need to treat it right, so it can stay healthy and do its job. Eat a healthy diet and get regular exercise. Your liver will thank you. You'll keep your weight under control, which helps prevent nonalcoholic fatty liver disease (NAFLD), a condition that leads to cirrhosis. Watch out for certain medicines. Some cholesterol drugs can occasionally have a side effect that causes liver problems. Alcoholic beverages can create many health problems. They can damage or destroy liver cells and scar your liver.

  • Track 21-1Diet and Exercise
  • Track 21-2 Hygiene
  • Track 21-3Alcohol use
  • Track 21-4 Vaccination

It is normal for the liver to contain some fat and by itself, this causes no symptoms. In some patients, the excess fat can cause inflammation called steatohepatitis. Steatohepatitis can lead to cirrhosis (fibrosis, scarring and hardening of the liver). There is also an association with liver cancer (hepatocellular carcinoma). Fatty liver can be classified as alcohol and nonalcohol related. Alcohol is a direct toxin to the liver and can cause inflammation. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic related steatohepatitis (NASH).

Obesity is a major health problem worldwide. Obesity also increases the risk of developing several diseases such as type II diabetes, insulin resistance, coronary heart disease (responsible for heart attacks), cerebrovascular disease (responsible for strokes), high blood pressure, gout, gallstones, colon cancer, sleep apnea, and a form of liver disease called nonalcoholic fatty liver disease (NAFLD). Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal complication that occurs in the third trimester or early postpartum period. Although the exact pathogenesis is unknown, this disease has been linked to an abnormality in fetal fatty acid metabolism. Early diagnosis of AFLP sometimes can be difficult because it shares features with other common conditions such as pre-eclampsia, viral hepatitis and cholestasis of pregnancy.

  • Track 22-1Alcoholic steatohepatitis
  • Track 22-2Acute fatty liver of pregnancy
  • Track 22-3Obesity and Liver Steatosis
  • Track 22-4Nonalcoholic Steatohepatitis

Liver cancer is the condition which occurs when normal cells in the liver become abnormal in appearance and destructive to the adjacent normal tissues, which can spread to other areas of liver or to the other organs outside of the liver. Cancer cells are characterized by the procurement of several capacities amid the stages of tumorigenesis, maintenance of proliferation signaling, induction of angiogenesis, activation of invasive resistance to cell death, inhibition of growth suppressors, and metastatic pathways, ability to evade immunological destruction and alteration of cellular metabolism. The clonogenic capacity of stem cells was evaluated by the stem cell colony formation assay.

  • Track 23-1Hepatocellular carcinoma
  • Track 23-2Cholangiocarcinoma
  • Track 23-3Angiosarcoma of liver
  • Track 23-4Hepatoblastoma
  • Track 23-5Liver cell carcinoma
  • Track 23-6Kupffer cell sarcoma
  • Track 23-7Hepatoma
  • Track 23-8Other sarcomas of liver

The molecular targets of interest have expanded from angiogenesis to cancer cell-directed oncogenic signaling pathways for advanced HCC treatment. The feasibility of combining locoregional therapies and targeted agents, and the use of novel agents after curative treatments are currently under active investigation. Finally, the therapeutic strategy has shifted from monotherapy to combination targeted therapy.

  • Track 24-1Partial Hepatectomy
  • Track 24-2Clinical Analysis of Cells
  • Track 24-3Intra - arterial Chemotherapy
  • Track 24-4AFP Blood Testing

Considering certain cases liver cancer occurs due to genetic inheritance. Due to recessive genes, the human body will not fight against the antigens as they are unable to recognize and produce antibodies against the antigens. Whole genome analysis technique is used to find the genomic aberrations; DNA hypo methylation promotes a diverse range of Liver cancers.

  • Track 25-1Whole Genome Analysis
  • Track 25-2Epigenetics of liver diseases
  • Track 25-3DNA Hypomethylation
  • Track 25-4Epigenomics of Diabetes and Other Metabolic Diseases

Liver diseases are mostly seen as in a grown-up, however, a huge number of children from babies to teens experience from different types of liver diseases. The volume of the liver and the blood flow decreases with age, immune responses against pathogens or neoplastic cells are lower in the elderly reducing their tolerability to treatments for liver diseases. Liver regeneration capacity shows a decline in age, reduced proliferation of hepatocytes, but the level of hepatic enzymes and high-density lipoprotein cholesterol is well maintained. Pediatric hepatology focuses on the diagnosis and treatment of liver and liver-related disease in infants and children.

  • Track 26-1Liver Failure
  • Track 26-2Liver Fibrosis
  • Track 26-3Liver Cirrhosis
  • Track 26-4Gilbert’s disease
  • Track 26-5Hepatorenal syndrome
  • Track 26-6Neonatal Jaundice
  • Track 26-7Hemochromatosis

Liver imaging is basically for precise diagnosing biliary tract issue and is imperative for identifying liver injuries or damage and patients with a suspected malignancy is important because the liver is the common site of metastatic spread and those who are at the risk of developing hepatocellular carcinoma.

  • Track 27-1Angiography
  • Track 27-2Computerized Tomography
  • Track 27-3Positron Emission Tomography
  • Track 27-4Ultrasonography
  • Track 27-5Magnetic Resonance Imaging

Liver transplant is an operation that replaces a replaces a person’s diseased heart with a partial or a whole liver from a donor. A rare condition in newborn infants is Biliary atresia in which the common bile ducts, which carry bile out of liver and present between the liver and small intestine is absent or blocked. Bariatric surgery performed on people, who have obesity through a variety of procedures. Removing a tissue sample (biopsy) from the liver may help diagnose liver disease. Liver biopsy is done using a long needle inserted through the skin to extract a tissue sample and then analyzed in a laboratory. 

  • Track 28-1Liver Biopsy
  • Track 28-2Bariatric surgery
  • Track 28-3Living donor transplantation
  • Track 28-4Graft rejection
  • Track 28-5Immunosuppressive management